Shire Scientist, Gene Therapy Vectorology in Cambridge, Massachusetts

Primary Duties

The Gene Therapy Scientist is responsible to support Discovery Research gene therapy programs. The incumbent will represent Discovery Therapeutics Gene Therapy team independently to participate in matrix project teams within Discovery Therapeutics (eg. Protein Engineering, Protein Expression, Analytics and Cell Line Developments) and with other major functions in Research and Non-Clinical Development to advance preclinical drug candidates in a highly collaborative manner. Efforts will contribute to the advancement of drug candidate through early research and early development.


  • Design and conduct hands-on experiments, to develop the gene therapy modality platform and to advance vector candidates in gene therapy projects.

  • Design, construction, optimize viral vector with the utilization of in silico tools.

  • Produce research scale vectors using adherent and/or suspension mammalian cells and purification of vectors using centrifugation and/or column-based chromatography methods.

  • Conduct in vitro­ cell-based experimental design, execution and data analysis to characterize biological properties of viral vectors and its transgene functions.

  • Perform DNA, RNA and/or protein extraction from tissue culture and animal tissue samples to be analyzed in assays specific to the biology of the transgene product

  • Develop a broad network and work effectively with internal collaborations and external CROs to deliver materials and reagents needed for gene therapy projects.

  • Represent Discovery Therapeutics Gene Therapy and participate in cross-functional project teams.

  • Communicate with members of Research, Non-Clinical Development and Process Development & Technical Services

  • Follow compliance of documentation in electronic lab notebook and author scientific reports that supports internal documentation and regulatory submissions.

  • Demonstrate good organizational and communication skills. Expected to be accountable for effectiveness and timelines of completion of project goals.

Education and Experience Requirements

  • PhD in virology, genetics, pharmacology or related biological science or M.S. with 5+ years of academic and/or industrial experience with strong track record of scientific publications.

  • Direct experience in the design and testing of research viral vectors for therapeutics application is required. Experience in development is a plus.

  • Ability to adapt to new and fast paced environment and navigate uncertainties

  • Expected to work independently as well as in a team setting, identify challenges and seek input from colleagues and supervisor for solutions to diverse problems, and demonstrate motivation in pursuing scientific answers through thorough experimental planning

  • Excellent interpersonal communication and written skills for presentations, report writing and day-to-day project team communications.

  • Data-driven, critical thinking, analytical and ability to interpret results with statistical approaches.

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Equal Employment Opportunity

Shire is an Equal Opportunity Employer committed to a diverse workforce. Shire will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

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Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.