Shire Scientist in Cambridge, Massachusetts

Primary Duties

The candidate will be responsible of laboratory work, including protein (and antibody) design, expression, production, purification, conjugation, and analysis of optimized lead and backup protein development candidates. The responsibilities of this role include independent planning, designing and execution of scientific experiments, interpreting and presenting scientific data. This candidate will have project coordinator responsibilities for Protein Engineering Discovery Projects (internal or external) and will actively provide scientific expertise to Discovery and Development teams as needed.


% of Time

Job Function and Description


Research Activities including experimental planning and direct laboratory activities, relevant and necessary literature review.


Communication with supervisor regarding experimental designs and results. Communication with members of Discovery Biology and Discovery Therapeutics Departments. Helping of team members to succeed in scientific experiments. Consultation with outside experts and collaborators.


Report writing and record keeping.

Education and Experience Requirements Life Sciences with emphasis on Molecular Biology or Cell Biology, and with five years of relevant working experiences a plus or Masters Degree with 7 years of industrial experience preferred or a Bachelors degree with 10 years of experience preferred.

Key Skills, Abilities, and Competencies

Knowledge in Molecular cloning, cell expression, purification and protein analytics is required. Candidates should have experience in designing expression constructs for mammalian, baculo-virus or bacteria expression system, and high throughput screening of engineered proteins. Evaluation of HT samples may require biochemical methodology such as small scale purification, ELISA, octet, enzyme activity assay, caliper, HPLC, SDS-PAGE and Western blot analysis techniques. Capability in proposing experimental design and developing relevant scientific method to characterize recombinant proteins in vitro is required. Implementation of new technologies to suit the changing needs of the Discovery Projects is necessary.

Other Job Requirements

Compliance to biohazard, radiation hazard and chemical hazard regulation is required.

Notice to Employment / Recruitment Agents:

Employment / Recruitment agents may only submit candidates for vacancies only if they have written authorization to do so from Shire’s Talent Acquisition department. Any agency candidate submission may only be submitted to positions opened to the agency through the specific Agency Portal. Shire will only pay a fee for candidates submitted or presented where there is a fully executed contract in place between the Employment / Recruitment agents and Shire and only if the candidate is submitted via the Agency Portal. Candidates submitted or presented by Employment / Recruitment Agents without a fully executed contract or submitted through this site shall not be deemed to form part of any Engagement for which the Agency may claim remuneration.

Equal Employment Opportunity

Shire is an Equal Opportunity Employer committed to a diverse workforce. Shire will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

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Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.