Shire Master Thesis: Application of Dynamic Light Scattering (DLS) on AAV particles in Orth an der Donau (Baxalta), Austria

Shire is the leading biotech company in rare diseases and sees a significant need for rare disease innovation. One example is Shire’s gene therapy hub in Orth an der Donau. In the past years the company has established a solid gene therapy platform based on adeno-associated viruses, which comprises vector optimization, analytical assays, scale-up expertise and a GMP-compliant production process. The experience gained in the process is also offered to external partners.

We are currently looking for a Master’s student to work with us on a project focusing purification and further characterization of several Adeno-Associated Virus particles

Master Thesis: Application of Dynamic Light Scattering (DLS) on AAV particles

Dynamic Light Scattering (DLS) is widely used to characterize protein, nanoparticles, colloids and macromolecules from subnanometers to several micrometers requiring relatively small amounts of samples. The main part of the work will consist of the purification and further characterization of several Adeno-Associated Virus particles, knowledge of which will be used to improve product stability and yield throughout the different product purification steps in a gene therapy process.

The master thesis includes dealing with different downstream unit operations (under supervision) for the purification of different AAV particles and the subsequent product characterization with DLS, as well as data analysis and evaluation of results. The output of this master thesis shall include the establishment of a library of tailored buffers for different AAVs and purification steps to accelerate the selection of optimal buffers during the downstream process development and increase yield. The duration of the master thesis will be limited to 6 months.

Qualifications:

  • Study of biotechnology or similar, ideally at BOKU or TU

  • Theoretical knowledge of upstream processing

  • Hands-on experience in fermentation would be an advantage

  • Advanced English skills

We offer outstanding opportunities to motivated people regardless of your gender, age, skin color, ethnicity, sexual orientation or physical handicaps. Diversity is part of our success!

The minimum salary for this position is € 1.490,56 gross per month (full-time); increased payment is possible. We are looking forward to your application on www.shire.com or www.shire.at

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Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.