At Shire, we are proud and grateful to employ military veterans and thank them for their contributions to our company and our country. See where your military experience can play a role at Shire by using our military skills translator job search tool below:
System One In Vivo Scientist in San Diego, California
Job Title: In Vivo Scientist
Location: San Diego, CA
Compensation: $75.00- $81.05
Leading Biopharmaceutical company looking for an experienced In vivo Scientist. Ideal candidate should have 5+ years of experience with in vivo studies, molecular biology techniques, xenograft and syngeneic models, and data analysis and presentation.
Independently design, plan, execute and interpret complex in vivo studies focused on identifying small and large candidate molecules and ADCs within the area of oncology.
Formulation of small and/or large molecules for in vivo studies.
Evaluation of pathway biomarkers and endpoints from in vivo studies via techniques such as flow cytometry, qPCR, IHC, ELISA, Mesoscale, Flow cytometry and Western blots.
Plan, execute and interpret pharmacokinetic/pharmacodynamic studies in acute and chronic disease models.
Data presentation to multidisciplinary discovery teams.
Participate in the evaluation of new targets.
Identification of risks within function and development of contingencies plans to mitigate risk.
Lead and manage the pharmacology staff assigned to them.
Interface with cross-functional teams and represent pharmacology on discovery teams and lead sub-teams.
Bachelor’s Degree with 5+ years of academic and / or industry experience
Master’s Degree with 3+ years of academic and / or industry experience
Ph.D. or equivalent advanced degree in the Life Sciences with No experience necessary
5+ years of in vivo studies
5+ molecular biology techniques
5+ xenograft and syngeneic tumor models
5+ years Data analysis and presentation
Proven track record in validating and implementing animal models for testing cancer therapies including xenograft and syngeneic tumor models. Experience with advanced humanized models is a plus.
In vivo skills include animal handling, dosing of small or large molecules, and ADC sample preparation, small animal surgeries, tissue sample collection, imaging modalities.
In vivo target validation and experience with more complex xenotransplantation, transgenic and knockout models is a plus.
Proficiency in laboratory bench skills such as ELISAs, Western blots, Mesoscale, qPCR, Nanostring, Flow cytometry, and/or histology is required. Experience with immunophenotyping of cells from various matrices is a plus.
Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale.
Detail oriented and able to problem solve and offer potential solutions.
Excellent written and oral communication skills. Ability to write protocols and technical reports with precision.
Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills. Supervisory experience is a plus.
Interface with cross-functional team members and present to multidisciplinary teams.
Computer skills: Advanced knowledge of Excel, Word, PowerPoint, FlowJo and GraphPad Prism. Experience with StudyLog software is a plus.
Local candidates preferred.
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
System One, and its subsidiaries including Joulé, ALTA IT Services, CM Access, TPGS, and MOUNTAIN, LTD., are leaders in delivering workforce solutions and integrated services across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible full-time employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.