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Thermo Fisher Scientific Senior Application Scientist, Oligonucleotides/mRNA LCMS Analysis in San Jose, California

Senior Application Scientist, Oligonucleotides/mRNA LCMS Analysis


When you're part of the team at Thermo Fisher Scientific, you'll do important work, and you'll be valued and recognized for your performance. With talented managers and inspiring coworkers to support you, you'll find the resources and opportunities to make significant contributions to the world.

How you will make an impact:

We are looking for a highly experienced and self-motivated individual to develop high resolution LCMS applications for oligonucleotides and mRNA analysis to meet biopharmaceutical industry's needs. As a member of the Thermo Fisher Scientific Pharmaceutical and Biopharmaceutical Vertical Marketing Applications Team (Chromatography and Mass Spectrometry), you will work within a highly matrixed organization to advance our thought leadership position within the regulated laboratory space.

What you will do:

  • Understand customer's business and analytical challenges and needs during nucleic acid drug discovery, development, manufacturing and quality control

  • Provide scientific guidance for strategic collaborations with KOLs

  • Creation of scientific proof statements for new chromatography, mass spectrometry, and software products relevant to the Pharma and Biopharma market

  • Align and prioritize application development with marketing strategies and priorities

  • Propose, design, and execute application plan to show case Thermo Fisher Scientific's analytical instrument portfolio for nucleic acid drug characterization and quality control

  • Proactively and timely address issues and challenges by providing regular feedback with product centers to address defects and feature gaps

  • Create, design, conduct & implement the experiments for advanced method development from sample preparation to LCMS analysis and data analysis

  • Generate compelling collateral assets (including but not limited to customer facing seminar modules, application notes, white papers and peer review publications) to demonstrate the competitive advantage of the application methods/solutions developed

  • Provide guidance and sales training material to educate and enable sales to demonstrate the application generated for commercial success

  • Present Thermo Fisher Scientific products and application solutions at meetings, conferences and seminars

How you will get here:


  • M.Sc. degree required, preferably in Analytical Chemistry or a related technical field.

  • PhD degree preferred


  • Minimum 5 years of hands-on experience developing LCMS-based methods for Oligonucleotide/mRNA and their delivery system characterization in a biopharmaceutical/biotech/CxO, an instrumentation company, or a research institute.

  • Understanding the process and structure/function relationship of these molecules is a strong plus.

Knowledge, Skills, Abilities:

  • Excellent oral / written communication and presentation skills are a necessity

  • Must demonstrate technical knowledge and ability to present to others in a clear and concise manner.

  • Highly motivated team member with strong interpersonal skills to effectively interact and communicate with internal partners and customers.

  • Ability to travel up to 30%

At Thermo Fisher Scientific , each one of our 80,000 extraordinary minds has a unique story to tell. Join us and contribute to our singular mission-enabling our customers to make the world healthier, cleaner and safer.

Thermo Fisher Scientific is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, creed, religion, color, national or ethnic origin, citizenship, sex, sexual orientation, gender identity and expression, genetic information, veteran status, age or disability status.